Abstract: Abstract Objective:To investigate expression and prognostic significance of ING4 and CDX2 in colorectal cancer.Methods:The expressions of ING4 and CDX2 proteins were detected by immunohistochemistry in colorectal cancer tissues from 99 cases of colorectal cancer and normal colorectal tissues from 30 corresponding para-cancerous normal tissues. The data for clinic outcomes were collected. The correlations between the expressions of ING4、CDX2 and clinicopathological parameters were also analyzed. Results: The positive expression rates of ING4 and CDX2 were 67.7% and72.7% in the colorectal cancer tissues,the positive rate were significantly lower in colorectal cancer than that innormal tissue group (p＜0.05)．Both of ING4 and CDX2 expressions in colorectal cancer tissues were correlated with histological grade,infiltration depth,lymph node metastasis and TNM staging(p＜0.05). The 5-year survival rate in the ING4 negative group(35.5%) was lower compared with the ING4 positive group (77.9%) ; The 5-year survival rate in the CDX2 negative group(48.1%) was lower compared with the CDX2 positive group (70.8%) . ING4 was positively correlated with CDX2. Conclusion: The expressions of ING4 and CDX2 are strongly associated with the carcinogenesis, development and prognosis of the cancer，which indicates that ING4 and CDX2 might be taken as prognostic markers for the colorectal cancer．

Key words: Colorectal cancer, ING4, CDX2, Prognosis