Study on the effectiveness of acute promyelocytic leukemia treated with combination therapy( arsenic trioxide with all-trans retinoic acid and chemotherapy)

Abstract

Abstract: Abstract Objective:To observe the effectiveness of arsenic trioxide(AS2O3)associated with all-trans retinoic acid (ATRA )and chemotherapy in treating acute promyelocytic leukemia(APL).Method:69 cases of APL was provided randomly two groups,37 cases in treating group with AS2O3+ATRA+chemotherapy,32 cases in control group with ATRA+ chemotherapy.To observe the effectiveness and side effect. Result:The first induce complete remission(CR)is 96.6% in the treating group,CR is 87.5% in the control group. The bad reaction related to the treatment no significant difference in two groups. Conclusion:Arsenic trioxide(AS2O3)associated with ATRA and chemotherapy had highter curative effect ,The combination is security.

Key words: leukemia promyelocytic acute, Arsenic trioxide, ATRA, Treatment

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Study on the effectiveness of acute promyelocytic leukemia treated with combination therapy( arsenic trioxide with all-trans retinoic acid and chemotherapy)

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