Abstract: Objective：To investigate the changes of coagulative and fibrinolytic function in elderly patients with both hypertension and type 2 diabetes. Methods：Plasma levels of von Willebrand’s factor(vWF）, fibrinogen(Fbg), prothombin fragment 1+2(F1+2), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1)were detected in 50 patients with essential hypertension, 50 patients with both hypertension and type 2 diabetes and in 30 healthy controls. Results：The plasma levels of vWF, Fbg, F1+2, t-PA and PAI-1 had significant differences among groups (P <0.05).The hypertension and type 2 diabetes group, the hypertension group presented a significant difference to the control group for the plasma levels of vWF, Fbg, F1+2, t-PA, PAI-1. The levels of F1+2, t-PA and PAI-1 had significant differences in the hypertension and type 2 diabetes group compared with those in the hypertension group (P <0.05). Conclusions：There was coagulative and fibrinolytic disturbance in elderly patients with both hypertension and type 2 diabetes. Molecular markers should be measured in those patients for prevention and treatment of thrombotic diseases.

Key words: Hypertension, Type 2 diabetes, Coagulation, Fibrinolysis