Abstract:

[Abstract] Objective To study the relationships among brachial-ankle pulse wave velocity (baPWV) , early renal function and left ventricular hypertrophy (LVH) in patients with essential hypertension. Methods Four hundred and twen? ty-seven patients aged60-90years were selected from the patients with essential hypertension. The patients were divided in? to four groups by quartile of the baPWV. Biochemical index were recorded. The eGFR were calculated using Cockcroft Gault formulation. Ultrasonic cardiogram(UCG) were employed to calculate the left ventriclar mass index (LVMI).Results There were significant differences in the age, ankle brachial index(ABI), systolic blood pressure(SBP), mean arterial pressure (MAP),pulse pressure(PP), fasting blood glucose(FBG), LVMI and eGFR among the four groups. Given the age and FBG , baPWV was positively correlated with SBP (r=0.295, P＜0.01), MAP(r=0.187, P＜0.01), PP(r=0.292, P＜0.01), LVMI(r= 0.159,P＜0.01), but negatively related to eGFR (r=-0.314, P＜0.01). Multiple linear regression analysis indicated that pressure(DBP) still were still independent risk factors of eGFR, after adjusting for other cardiovascular risk factors, age, baP? WV and diastolic blood (t=8.251，6.834，2.142，P＜0.05). Systolic blood pressure(SBP) and ankle brachial index(ABI) were independent risk factors of LVMI ( t=4.557,3.016，P＜0.05), but the baPWV was not an assured independent risk factor of LVMI(t=1.722, P=0.086). Conclusion baPWV played an important role in evaluating the cardiovascular risk factors and early renal dysfunction caused by hypertension.

Key words: Pulse wave velocity, Hypertension, Glomerular filtration rate, Left ventricular hypertrophy