Abstract:

[Abstract] Objective To investigate the relationship between the level of8-iso-prostaglandin (8-iso-PG)F2αand the neural functional deficit in patients with acute cerebral infarction (ACI). Methods Sixty-seven ACI patients were se? lected in Neurological Department of Ganyu People’s Hospital. According to the age, these subjects were divided into two groups: the old group (≥60years,n=37) and middle-young group (<60years,n=30). Thirty healthy subjects were selected as controls (≥60years). The age, gender and anamnesis were matched in two groups of elderly people. The ELISA was used to detect the plasma levels of8-iso-PGF2αin two groups of patients. And NIHSS score was used to evaluate the severity of clinical neurological deficit. Results The plasma levels of8- iso- PGF2αwere significantly higher in old ACI group (506.38±138.63) ng/L than those of middle-young ACI group (420.18±132.72) ng/L and old control group (369.98±99.81) ng/L. There was no significant difference in plasma level of8-iso-PGF2αbetween middle-young ACI group and old control group (F=9.272，P＜0.05). The NIHSS score was significantly higher in old group (19.78±3.66) than that of middle-young group (17.73±2.70, t=2.539，P＜0.05). There was a positive correlation between plasma 8- iso- PGF2αlevel and NIHSS score in old group (r=0.504，P=0.001). Conclusion The oxidative stress plays an important role in the occurrence and de? velopment process of ACI in elderly patients. The earlier and reasonable antioxidant therapy plays a positive role to alleviate the clinical symptoms and promote the recovery of illness.

Key words: cerebral infarction, oxidation, 8-iso-PGF2a, old age