Abstract: Objective  To discuss the impact and clinical significance of HP elimination on ghrelin, by detect the difference of serum ghrelin level and ghrelin express in gastric mucosa before and after HP elimination on upper gastrointestinal disease patients. Method    Determine serum ghrelin level before and after HP elimination with ELISA. Determine ghrelin express in gastric mucosa with RT-PCR. Analysis results with statistical method. Result   Serum ghrelin level in HP infected chronic superficial gastritis group, atrophic gastritis group, peptic ulcer group and gastric cancer group are 26.08±9.14μg/L, 18.59±8.19μg/L, 35.42±9.87μg/L and 18.33±6.88μg/L. Ghrelin express in gastric mucosa are 0.86±0.26, 0.75±0.22, 1.38±0.29 and 0.21±0.09. In chronic superficial gastritis group, both serum ghrelin level and ghrelin express in gastric mucosa were found risen to 29.35±8.83μg/L and 1.10±0.32（P<0.01） 4 weeks after HP elimination therapy. In peptic ulcer group, both serum ghrelin level and ghrelin express in gastric mucosa were found decreased to 30.73±6.50μg/L and 1.09±0.24（P<0.01）. In atrophic gastritis group, significant ghrelin changes were not found before and after HP elimination. Serum PGI/PGII and serum ghrelin were found positively related in chronic superficial gastritis group, atrophic gastritis group and gastric cancer group, r=0.668（P<0.01）. Conclusion  HP infection and HP eliminate rained influence on ghrelin level in patients with HP related upper gastrointestinal diseases. The changes of ghrelin level related on pepsinogen I/II. Ghrelin could be used as one of the indexes of gastric mucosa degree of diagnostic and prognostic evaluation.

Key words: helicobacter pylori, growth hormone-releasing hormone, gastritis, atrophic, peptic ulcer, stomach neoplasms, adenocarcinoma, 腺癌