Abstract: Objective To investigate the effects of high loading dose of atorvastatin on lipoprotein-associated phospho⁃ lipase A2 (Lp-PLA2) and inflammatory cytokines in patients with acute myocardial infarction (AMI), who underwent emergen⁃ cy percutaneous coronary intervention (PCI). Methods A total of 65 cases with AMI who underwent emergency PCI be⁃ tween October 2011 and August 2013 were randomly divided into two groups: control group (n=32, atorvastatin 20 mg/24 h) and high dose atorvastatin group (n=33, atorvastatin 40 mg/24 h). Two groups of patients were given the same basic treat⁃ ment. Blood samples were obtained before treatment and 72 h after PCI in two groups. Levels of Lp-PLA2, interleukin-6 (IL- 6), tumor necrosis factor- α (TNF-α), alanine transaminase (ALT) and aspartate transaminase (AST) were detected in two groups. The adverse drug reactions were observed. Results There were no significant differences in Lp-PLA2, IL-6, TNF- α, ALT and AST levels between two groups (P＞0.05). After PCI, the levels of Lp-PLA2, IL-6 and TNF-α were significantly increased compared with those of baseline in two groups, and they were more notable in control group than those of high dose atorvastatin group (P＜0.05). The levels of ALT and AST were also significantly higher after operation compared with those of basic levels (P＜0.05), while there were no significant differences in ALT and AST after PCI between two groups (P＞0.05). Conclusion The high loading dose of atorvastatin in AMI patients underwent emergency PCI can de⁃ crease the inflammation and stabilize the plaques in acute stage, and which is safe.

Key words: simvastatin, myocardial infarction, angioplasty, transluminal, percutaneous coronary, phospholipases A2, Atorvastatin