Abstract: Objective To assess clinical efficacy of comprehensive treatment on chronic sinusitises (CRS) with neutrophils infiltration and eosinophilic infiltration as pathological features. Methods A total of 256 CRS patients whose symptoms were not been improved after surgery (visual analog scale＞6， 3 months after surgery) were included in this study. Different comprehensive treatments were given to the patients according to the different types of cell infiltration. The visual analog scale (VAS), Lund-Kennedy and nasal histopathological examination were observed after treatment in patients. Results After different comprehensive treatments, the VAS and Lund-Kennedy were improved in patients with eosinophils infiltration, but the number of eosinophils was not reduced. The VAS, Lund-Kennedy and the number of neutrophils were significantly improved in patients with mainly neutrophils infiltration. Conclusion According to different immune pathological characteristics, patients of CRS should be given different comprehensive treatments. There is a obvious efficacy for patients with neutrophil infiltration.

Key words: rhinitis, sinusitis,  chronic disease,  neutrophil infiltration, eosinophils, surgical procedures, operative, combined modality therapy