Abstract: Objective To observe the clinical curative effect of compound polymyxin B ointment combined with basic fibroblast growth factor (bFGF) on wound surface of deep second-degree burn in children, and provide reference for the clinical treatment. Methods Eighty cases of children patients with deep second-degree burn were included in this study, who were admitted in Tianjin 4th Center Hospital from March 2015 to March 2016. The cases were divided into control group and combined treatment group, 40 cases for each group. Wherein, the control group was treated with bFGF, the combined treatment group was received compound polymyxin B ointment and bFGF. The occurrence rate of infection of burn wound surface, wound healing time and occurrence rate of scar after healing were compared between two groups. Results There were lower infection rates on day 7, 10, 15 and 20 after burn in combined treatment group than those in control group (P< 0.05). The healing time was significantly shorter in combined treatment group than that in control group [(21.53±1.33) d vs. (25.76±1.50) d, t=13.345, P < 0.01]. The scar occurrence was significantly lessin combined group than that of control group (U=5.077， P < 0.05). Conclusion The compound polymyxin B ointment combined with bFGF show a certain effect of antiinfection, acceleration of wound surface healing and preventing the scar from generating for wound surface on deep seconddegree burn in children, which having a significant clinical curative effect.

Key words: burns, polymyxin B, basic fibroblast growth factor 2, cicatrix, wound infection, child