天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (2): 146-151.doi: 10.11958/20193672

• 综述 • 上一篇    下一篇

线粒体功能障碍在心血管疾病中作用机制的研究进展

王丽艳，徐哲龙△   

  1. 天津医科大学基础医学院生理学与病理生理学系（邮编300070）
  • 收稿日期:2019-12-05 修回日期:2020-01-29 出版日期:2020-02-15 发布日期:2020-02-15
  • 通讯作者: 王丽艳 E-mail:wliyan@tmu.edu.cn
  • 基金资助:
    STAT3锌感应效应在心肌再灌注损伤中的作用

The role of mitochondrial dysfunction in cardiovascular diseases

WANG Li-yan, XU Zhe-long△   

  1. Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China
  • Received:2019-12-05 Revised:2020-01-29 Published:2020-02-15 Online:2020-02-15
  • Contact: Li YanWANG E-mail:wliyan@tmu.edu.cn

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摘要： 摘要：线粒体是细胞的能量代谢中心，其通过氧化磷酸化产生能量以满足心脏的高能量需求。心脏许多重要的 生理活动，如心肌收缩和细胞内稳态的维持均需要线粒体产生的三磷酸腺苷（ATP）。因此，完整的线粒体结构和功 能是心脏进行正常生理活动的前提和基础。以呼吸链功能异常和ATP合成障碍为特征的线粒体功能障碍是许多心 血管疾病的发病原因。因此，在疾病早期进行线粒体质量控制、减少线粒体功能障碍和氧化应激成为心血管疾病治 疗的新靶标。本文对线粒体功能障碍在心血管疾病中的作用机制以及相关的新型治疗策略展开综述。

关键词: 线粒体, 活性氧, 心血管疾病, 线粒体功能障碍

Abstract: Abstract: Mitochondrion as the energy metabolism center of cells, meet the high energy demand of heart through oxidative phosphorylation. Cardiac activities such as myocardial contraction and intracellular homeostasis are powered by mitochondrial ATP. The integrity and proper function of mitochondria are fundament of cardiac physiological activities. The mitochondrial dysfunction characterized by abnormal respiratory chain function and ATP synthesis deletion is involved in the development of many cardiovascular diseases. In the early stage of diseases, the mitochondrial quality control, the prevention of mitochondrial dysfunction and oxidative stress have become a new therapeutic target to reduce cardiac damage and improve cardiac function in cardiovascular diseases. This paper reviews the mechanisms of mitochondrial dysfunction in cardiovascular diseases and the related novel therapeutic strategies.

Key words: mitochondria, reactive oxygen species, cardiovascular diseases, mitochondrial dysfunction