宫腔灌注丹红注射液对薄型子宫内膜患者FET结局的影响

doi:10.11958/20220412

天津医药 ›› 2022, Vol. 50 ›› Issue (9): 970-974.doi: 10.11958/20220412

宫腔灌注丹红注射液对薄型子宫内膜患者FET结局的影响

董融(), 王宝娟, 马赛花, 张玙, 邱韵桓, 夏天

天津中医药大学第一附属医院生殖中心/国家中医针灸临床医学研究中心（邮编300381）

收稿日期:2022-03-18 修回日期:2022-06-10 出版日期:2022-09-15 发布日期:2022-09-05
作者简介:董融（1986）,女,主治医师,主要从事妇产科学辅助生殖技术方面研究。E-mail： 13821908081@163.com
基金资助:
天津市教委科研计划项目(2019KJ047)

The effect of intrauterine infusion of danhong injection on pregnancy outcome of frozen-thawed embryo transfer in patients with thin endometrium

DONG Rong(), WANG Baojuan, MA Saihua, ZHANG Yu, QIU Yunhuan, XIA Tian

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncuture and Moxibustion, Tianjin 300381, China

Received:2022-03-18 Revised:2022-06-10 Published:2022-09-15 Online:2022-09-05

董融, 王宝娟, 马赛花, 张玙, 邱韵桓, 夏天. 宫腔灌注丹红注射液对薄型子宫内膜患者FET结局的影响[J]. 天津医药, 2022, 50(9): 970-974.

DONG Rong, WANG Baojuan, MA Saihua, ZHANG Yu, QIU Yunhuan, XIA Tian. The effect of intrauterine infusion of danhong injection on pregnancy outcome of frozen-thawed embryo transfer in patients with thin endometrium[J]. Tianjin Medical Journal, 2022, 50(9): 970-974.

摘要/Abstract

摘要：

目的探讨宫腔灌注丹红注射液对血瘀型薄型子宫内膜患者冻融胚胎移植（FET）结局的影响。方法选择接受FET治疗的薄型子宫内膜所致不孕症患者66例,采用随机数字表法分为治疗组和对照组,每组33例。患者均于月经第8~10天开始监测卵泡发育,卵泡直径14~18 mm时治疗组使用丹红注射液隔日进行宫腔灌注治疗,同一周期共灌注2~3次,对照组不予任何干预。比较治疗后2组注射人绒毛膜促性腺激素（HCG）日子宫内膜厚度、子宫内膜血流类型、活产率、β-HCG阳性率、临床妊娠率、持续妊娠率、早期流产率、周期取消率以及胚胎种植率。结果治疗组活产率、β-HCG阳性率及持续妊娠率优于对照组,且治疗组HCG日子宫内膜厚度和子宫内膜血流类型优于对照组,差异有统计学意义（P<0.05）。2组患者周期取消率、胚胎种植率、早期流产率、临床妊娠率差异无统计学意义（P>0.05）。结论宫腔灌注丹红注射液可改善薄型子宫内膜患者FET后的妊娠结局,且安全性良好。

关键词: 灌流, 丹参, 红花, 注射剂, 子宫内膜, 丹红注射液, 薄型子宫内膜, 子宫内膜容受性

Abstract:

Objective To investigate the effect of intrauterine infusion of danhong injection on the outcome of freeze-thawing embryo transfer (FET) in patients with thin endometrium caused by blood stagnation. Methods Sixty-six patients with infertility caused by thin endometrium and treated with FET were enrolled and randomly divided into the treatment group and the control group by random number table method, with 33 cases in each group. In the treatment group, follicular development was monitored from the day 8 to 10 of menstrual cycle, and danhong injection was used for intrauterine infusion every other day when the follicle diameter reached 14 mm to 18 mm. A total of 2-3 times of treatment were performed, while no intervention was given to the control group. After treatment, the endometrial thickness, endometrial blood flow type, live birth rate, positive rate of β-HCG, clinical pregnancy rate, ongoing pregnancy rate, early abortion rate, cycle cancellation rate and embryo implantation rate on human chorionic gonadotropin (HCG) injection day were compared between the two groups. Results The live birth rate, positive rate of β-HCG and persistent pregnancy rate were significantly better in the treatment group than those in the control group, and the endometrial thickness and endometrial blood flow type on ovulation day were significantly better in the treatment group than those in the control group (P<0.05). There were no significant differences in cycle cancellation rate, embryo implantation rate, early abortion rate and clinical pregnancy rate between the two groups (P>0.05). Conclusion Intrauterine infusion of danhong injection can improve pregnancy outcome in patients with thin endometrium with good safety.

Key words: perfusion, salvia miltiorrhiza, carthamus tinctorius, injectio, endometrium, thin endometrium, danhong injection, endometrial receptivity

中图分类号:

R271.9

图/表 3

表1 2组一般资料比较

Tab.1 Comparison of the general data between the two groups

组别	n	年龄（岁）	BMI（kg/m²）	不孕类型
组别	n	年龄（岁）	BMI（kg/m²）	原发不孕	继发不孕
对照组	33	32.64±2.06	22.65±1.37	10（30.3）	23（69.7）
治疗组	32	32.84±2.42	22.58±1.48	8（25.0）	24（75.0）
t或 $χ$ ²		0.372	0.199	0.228

表1 2组一般资料比较

Tab.1 Comparison of the general data between the two groups

组别	n	年龄（岁）	BMI（kg/m²）	不孕类型
组别	n	年龄（岁）	BMI（kg/m²）	原发不孕	继发不孕
对照组	33	32.64±2.06	22.65±1.37	10（30.3）	23（69.7）
治疗组	32	32.84±2.42	22.58±1.48	8（25.0）	24（75.0）
t或 $χ$ ²		0.372	0.199	0.228

表2 2组内膜相关数据比较

Tab.2 Comparison of the intima-related data between the two groups

组别	n	内膜厚度		子宫内膜血流类型
组别	n	≤7 mm	>7 mm	Ⅰ型	Ⅱ型	Ⅲ型
对照组	33	18	15	18（54.5）	11（33.3）	4（12.1）
治疗组	32	7	25	5（15.6）	22（68.8）	5（15.6）
$χ$ ²		7.326^＊		11.113^＊

表2 2组内膜相关数据比较

Tab.2 Comparison of the intima-related data between the two groups

组别	n	内膜厚度		子宫内膜血流类型
组别	n	≤7 mm	>7 mm	Ⅰ型	Ⅱ型	Ⅲ型
对照组	33	18	15	18（54.5）	11（33.3）	4（12.1）
治疗组	32	7	25	5（15.6）	22（68.8）	5（15.6）
$χ$ ²		7.326^＊		11.113^＊

表3 2组妊娠结局比较 [例（%）]

Tab.3 Comparison of pregnancy outcomes between the two groups

组别	周期数	活产率	β-HCG 阳性率	临床妊娠率	持续妊娠率	早期流产率
对照组	33	3（9.1）	8（24.2）	6（18.2）	5（15.2）	2（6.1）
治疗组	32	11（34.4）	16（50.0）	12（37.5）	12（37.5）	1（3.1）
$χ$ ²		6.146^＊	4.628^＊	3.028	4.201^＊	0.318

表3 2组妊娠结局比较 [例（%）]

Tab.3 Comparison of pregnancy outcomes between the two groups

组别	周期数	活产率	β-HCG 阳性率	临床妊娠率	持续妊娠率	早期流产率
对照组	33	3（9.1）	8（24.2）	6（18.2）	5（15.2）	2（6.1）
治疗组	32	11（34.4）	16（50.0）	12（37.5）	12（37.5）	1（3.1）
$χ$ ²		6.146^＊	4.628^＊	3.028	4.201^＊	0.318

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宫腔灌注丹红注射液对薄型子宫内膜患者FET结局的影响

The effect of intrauterine infusion of danhong injection on pregnancy outcome of frozen-thawed embryo transfer in patients with thin endometrium

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