Abstract: Pancreatic cancer is a kind of malignant tumor with extremely high mortality rate, and its onset is insidious and it develops rapidly. It is very easy to have lymphatic node and liver metastasis in early stage. At present, the research on the mechanism of invasion and metastasis of pancreatic cancer is getting deeper. This review summarized mainly by miRNAs, non encoded RNAs, hypoxia and epidermal growth factor (EGF) and its receptors, CXCL12 and FOXM1, DCLK1 protein molecules, which played the role in invasion and metastasis of pancreatic cancer. They act on target genes or related signaling pathways to promote cell proliferation, inhibit cell apoptosis and promote angiogenesis and EMT in tumor cells. They also alter tumor cell metabolism, which is closely related to malignant progress, invasion and metastasis in the pancreatic cancer.

Key words: pancreatic neoplasms, neoplasm invasiveness, neoplasm metastasis, review