Abstract: Abstract: Objective To analyze extremely early application of noninvasive ventilator in patients with acute heart failure. Methods A total of 100 patients with acute heart failure who were admitted and treated in Cardiac Intensive Care Unit (CICU) from January 2017 to December 2018 were studied retrospectively. Patients were divided into the extremely early application group (n=44) and the control group (n=56). Patients of two groups were given nasal tube oxygenation to reduce cardiac load, control heart rate and blood pressure, and improve myocardial metabolism after the onset of acute heart failure. On the basis of routine treatment, the application group was given extremely early application (10-30 min) of noninvasive ventilator assisted ventilation, and the control group was given noninvasive ventilator assisted ventilation in 30 min -24 h after onset. There were no significant differences in gender, clinical symptoms and vital signs before treatment between the two groups (P＞0.05). Data of respiratory rate (RR), resting heart rate (HR), mean arterial pressure (MAP), arterial blood oxygen partial pressure [p(O2)], arterial blood carbon dioxide partial pressure [p(CO2)] and lactic acid (Lac) were monitored before and 24 h after treatment. The serum levels of N-terminal B-brain natriuretic peptide (NT-proBNP) were also recorded before and after 1 week of treatment. The total efficacy rate was compared between the two groups. Results There were no significant differences in the related indicators before treatment between two groups of patients. The RR, HR, MAP and p(O2) were significantly improved after 24 h-treatment in the extremely early application group than those of control group (P＜0.05). Values of p(CO)2, Lac and NT-proBNP were significantly decreased in the extremely early application group than those of the control group (P＜0.05). The total efficacy rates were 90.91% in the early application group and 82.14% in the control group. There was no significant difference between the two groups (P＞0.05). Conclusion The extremely early application (10-30 min) of noninvasive ventilator assisted therapy has significant effect on patients with acute heart failure.

Key words: heart failure, noninvasive ventilation, natriuretic peptide, brain, mean arterial blood pressure