Abstract: Abstract: Atherosclerosis is a chronic vascular disease with high morbidity and mortality. Although the current treatment has achieved certain therapeutic effects, it has the characteristics of long treatment cycle, large adverse reactions and invasiveness. Sonodynamic therapy (SDT) has become a hot topic in current research because of its non-invasive nature, less impact on normal tissues, strong tissue penetration and no significant attenuation of energy. SDT can cause cell apoptosis and autophagy, improve lipid deposition, reduce inflammatory cell infiltration, promote vascular smooth muscle cell repopulation and prevent matrix degradation, and it is a potential treatment for atherosclerosis. The effects of SDT on atherosclerosis and its mechanisms are summarized below.

Key words: atherosclerosis, apoptosis, autophagy, sonodynamic therapy, sound sensitizer