Abstract: Objective To explore the influencing factors of tinnitus and cerebrospinal fluid leakage in patients with
acoustic neuroma after microsurgery. MethodsA total of 127 patients with acoustic neuroma treated in the department of
neurosurgery of our hospital from October 2017 to January 2020 were selected as the study objects. Patients were divided
into large tumor group (43 cases), medium tumor group (46 cases) and small tumor group (38 cases) according to the long
diameter of tumor. The incidence of tinnitus and cerebrospinal fluid leakage was compared between the three groups. The
influencing factors of tinnitus and cerebrospinal fluid leakage after acoustic neuroma microsurgery were analyzed. Results
Among the 127 patients, 54 (42.52%) cases of tinnitus occurred and 49 (38.58%) cases of cerebrospinal fluid leakage
occurred after operation. The incidence of tinnitus was higher in the large tumor group than that in the small tumor group
(P＜0.017). The incidence of cerebrospinal fluid leakage was higher in the large tumor group than that in the small and
medium tumor group (P＜0.017). Compared with the non tinnitus group, the tinnitus group had a longer course of disease, a higher proportion of preoperative internal auditory canal enlargement, a higher proportion of internal auditory canal posterior wall abrasion, and a longer operation time (P＜0.05). Compared with the group without cerebrospinal fluid leakage, the group with cerebrospinal fluid leakage had older age, longer course of disease, higher proportion of preoperative expansion of internal auditory canal, higher proportion of partial abrasion of posterior wall of internal auditory canal and longer operation time (P＜0.05). Larger tumor size was an independent risk factor for tinnitus after acoustic neuroma operation (P＜0.05), and larger tumor size and longer operation time were independent risk factors for the cerebrospinal fluid leakage after acoustic neuroma operation (P＜0.05). Conclusion The early detection of acoustic neuroma can reduce the risk of tinnitus and cerebrospinal fluid leakage after acoustic neuroma microsurgery.

Key words: neuroma, acoustic, microsurgery, tinnitus, cerebrospinal fluid leakage, Logistic models, tumor length