Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after
spinal cord injury

doi:10.11958/20212072

Tianjin Medical Journal ›› 2022, Vol. 50 ›› Issue (4): 439-443.doi: 10.11958/20212072

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Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury

SUN Ruixin1, 2, ZHAO Shuaishuai1, 2, SHEN Yuzhe1, 2, LIANG Jiaxing1, 2, YANG Yanling1, 2△ #br#

1 School of Medicine, Yan'an University, Yan'an 716000, China; 2 Yan'an Key Laboratory of Neuroscience △Corresponding Author and Revisor E-mail: yangyanling8889@163.com

Received:2021-09-08 Revised:2021-12-21 Published:2022-04-15 Online:2022-04-15

SUN Ruixin, ZHAO Shuaishuai, SHEN Yuzhe, LIANG Jiaxing, YANG Yanling. Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury[J]. Tianjin Medical Journal, 2022, 50(4): 439-443.

Abstract

Abstract: PI3K/AKT/mTOR signaling pathway is a classic autophagy pathway after spinal cord injury. Neuronal apoptosis, axon demyelination and inflammatory response after spinal cord injury are regulated by PI3K/AKT/mTOR signaling pathway, and are related to neuronal autophagy. This paper introduces the main role of PI3K/AKT/mTOR signaling pathway and neuronal autophagy response after spinal cord injury, hoping to provide reference for further research on spinal cord injury.

Key words: spinal cord injury, autophagy, PI3K/AKT/mTOR signaling pathway

CLC Number:

R651.21
','1');return false;" target="_blank"> R651.21

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Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury

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