Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after
spinal cord injury

doi:10.11958/20212072

Tianjin Medical Journal ›› 2022, Vol. 50 ›› Issue (4): 439-443.doi: 10.11958/20212072

Previous Articles Next Articles

Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury

SUN Ruixin1, 2, ZHAO Shuaishuai1, 2, SHEN Yuzhe1, 2, LIANG Jiaxing1, 2, YANG Yanling1, 2△ #br#

1 School of Medicine, Yan'an University, Yan'an 716000, China; 2 Yan'an Key Laboratory of Neuroscience △Corresponding Author and Revisor E-mail: yangyanling8889@163.com

Received:2021-09-08 Revised:2021-12-21 Published:2022-04-15 Online:2022-04-15

SUN Ruixin, ZHAO Shuaishuai, SHEN Yuzhe, LIANG Jiaxing, YANG Yanling. Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury[J]. Tianjin Medical Journal, 2022, 50(4): 439-443.

Abstract

Abstract: PI3K/AKT/mTOR signaling pathway is a classic autophagy pathway after spinal cord injury. Neuronal apoptosis, axon demyelination and inflammatory response after spinal cord injury are regulated by PI3K/AKT/mTOR signaling pathway, and are related to neuronal autophagy. This paper introduces the main role of PI3K/AKT/mTOR signaling pathway and neuronal autophagy response after spinal cord injury, hoping to provide reference for further research on spinal cord injury.

Key words: spinal cord injury, autophagy, PI3K/AKT/mTOR signaling pathway

CLC Number:

R651.21
','1');return false;" target="_blank"> R651.21

[1]	FANG Jie, HUANG Rui, ZHENG Honghui, JIA Qianqian, BAO Jing. miR-9-5p-induced autophagy and apoptosis in multiple myeloma cells by targeting TIMP2 [J]. Tianjin Medical Journal, 2024, 52(8): 785-790.
[2]	LI Daqiang, LI Jian, LU Zheming, CAO Yang. Effects of calycosin on neuronal autophagy and apoptosis in rats with spinal cord injury [J]. Tianjin Medical Journal, 2024, 52(8): 798-803.
[3]	WANG Ke, YE Hanlu. Impacts of cryptotanshinone on autophagy and apoptosis of chondrocytes in rabbit model of knee osteoarthritis by regulating HIF-1α/BNIP3 signaling pathway [J]. Tianjin Medical Journal, 2024, 52(4): 372-378.
[4]	HE Ying, ZHANG Guanghua, TIAN Lidong, YU Yonghao. Hydrogen-rich saline treated neuropathic pain in rats by increasing autophagy [J]. Tianjin Medical Journal, 2024, 52(3): 261-265.
[5]	WANG Aihua, ZHANG Feizhong, WANG Hongying. Impacts of muscone on malignant progression of ovarian cancer cells by regulating SHH mediated autophagy [J]. Tianjin Medical Journal, 2024, 52(2): 142-147.
[6]	ZHAO Yuanyuan, WU Xiaohua. The effect of LINC00173 regulating autophagy of PCOS granulosa cells based on PI3K/Akt/mTOR signaling pathway [J]. Tianjin Medical Journal, 2024, 52(11): 1121-1126.
[7]	ZHANG Rui, CHEN Sisi, WANG Tongdan, YU Pei. Krüppel-like factor 4 alleviated cholesterol deposition in macrophages by promoting autophagy at high glucose concentration [J]. Tianjin Medical Journal, 2024, 52(10): 1014-1019.
[8]	QIAO Na, TIAN Ying, CHEN Yang, HAO Jing. Impacts of lncRNA MALAT1 on apoptosis, autophagy of granulosa cells and PI3K/Akt/mTOR pathway in polycystic ovary syndrome [J]. Tianjin Medical Journal, 2024, 52(10): 1020-1024.
[9]	YANG Yuan, SONG Shuang, CHEN Rong, LIU Yonglian, LIU Chunyan. Study of ginsenoside Rg1 antagonizes sodium arsenite-induced nephrotoxicity in C57BL/6 mice [J]. Tianjin Medical Journal, 2023, 51(8): 820-824.
[10]	ZHU Jinghui, WEI Dongmin, REN Shuting, YANG Yanling, ZHAO Lin. Research progress of targeted inhibition of NLRP3 inflammasome in spinal cord injury [J]. Tianjin Medical Journal, 2023, 51(7): 781-784.
[11]	HUANG Chengjun, XU Yu, MI Le, WANG Xiujun, LIU Zhenfeng, WANG Hongman. Research progress of autophagy in acute respiratory distress syndrome [J]. Tianjin Medical Journal, 2023, 51(6): 668-672.
[12]	WANG Fei, ZHANG Xiaolei, LI Hanzhang, LI Yanan, HU Mengni, MA Jun. Effects of inhibiting PI3K/Akt/mTOR signaling pathway on autophagy, apoptosis and PD characteristic expression proteins in MPP⁺-treated SH-SY5Y cells [J]. Tianjin Medical Journal, 2023, 51(5): 449-453.
[13]	GENG Yongzhi, YANG Li, LI Guowei, ZHANG Jintao, CHENG Xiaolei, TAN Liduan. Study on the improvement effect and mechanism of nobiletin on rats with acute kidney injury [J]. Tianjin Medical Journal, 2023, 51(5): 498-503.
[14]	TAN Chunlian, LI Xiaohong, XIA Guodong, ZHANG Zhihong, LI Xiaoming. Inhibitory effect and mechanism of metformin on diffuse large B-cell lymphoma cells [J]. Tianjin Medical Journal, 2023, 51(4): 355-359.
[15]	WU Qiong, LI Jinyuan, HUANG Wentao, AN Na. Effects of acacetin on proliferation, apoptosis and migration of hepatocellular carcinoma HepG2 cells and its mechanism [J]. Tianjin Medical Journal, 2023, 51(3): 235-239.

Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury

Cite this article

PDF (PC)

Knowledge

Abstract

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments