Abstract: Objective To investigate the correlation of cyclophilin A (CyPA) level in patients with essential hyperten⁃ sion（EH）in Xinjiang Xibo and Mongolia populations and to investigate its clinical significance. Methods EH patients (n= 76) and healthy control subjects (n=62) were selected from Xinjiang Xibo populations. On the other hand, EH patients (n=66) and healthy control subjects (n=57) were selected from Xinjiang Mongolia populations. Serum cyclophilin A was measured using enzyme-linked immunosorbent assay（ELISA）. Parameters such as age, body mass index（BMI）, waist, waist hip ratio, blood pressure were measured in each group. The correlation of cyclophilin A with each parameter was analyzed. Results The levels of serum cyclophilin A in EH patients in Xinjiang Xibo and Xinjiang Mongolia populations were significantly high⁃ er than those in their corresponding healthy control groups(P＜0.05). Serum cyclophilin A in patients with essential hyperten⁃ sion（EH）in Xinjiang Mongolia population was signifantly higher than that in EH patients from Xinjiang Xibo population (P＜0.05). There was a positive correlation between serum cyclophilin A level and occurance of EH in both Xinjiang Xibo and Xinjiang Mongolia populations. Conclusion The serum cyclophilin A is significant higher in EH patients in both Xinji⁃ ang Xibo and Xinjiang Mongolia populations so it is positively correlated with occurance of EH (P＜0.05). Cyclophilin A lev⁃ el is a risk factor of essential hypertension in both Xinjiang Xibo and Xinjiang Mongolia populations.

Key words: hypertension, cyclophilin A, blood pressure, Xibo populations, Mongolia populations