Abstract: Objective: To investigate the role they play in occurring and developing of cerebral infarction, this study focuses on the concentration of serum bilirubin and uric acid in patients with cerebral infarction. Method: All the 233 patients with cerebral infarction were taken fasting blood sample to detect serum total bilirubin, direct bilirubin, indirect bilirubin, uric acid. Control group includes 187 healthy employees of our hospital. Result: The concentration of serum total bilirubin and direct bilirubin in patients with cerebral infarction is statistically higher versus controls（P=0.031，0.000）. Moderate and sever group has higher serum bilirubin concentration compare with mild group（P<0.05）. A statistically significant rise in serum bilirubin was found in patients with acute cerebral infarction compare with sub-acute group and controls（P<0.05）, but the sub-acute group doesn’t have significant difference with controls. The concentration of serum uric acid in patients with cerebral infarction is statistically higher versus controls（P=0.007）. Moderate and sever group has lower serum uric acid concentration compare with mild group（P=0.021）. A statistically significant rise in serum uric acid was found in patients with acute and sub-acute cerebral infarction patients compare with controls（P<0.05）, but no significant difference was found between acute group and sub-acute group. Conclusion: Serum bilirubin, as an anti-oxidant, elevates during acute period and decreases during sub-acute period. The more severe the neurological dysfunction is, the higher serum bilirubin appears. The increase of serum uric acid is not just at acute period after cerebral infarction. After acute period, the serum uric acid is still high due to atherosclerosis. The moderate and severe group has lower serum uric acid maybe because consumption of uric acid as anti-oxidant.

Key words: Cerebral infarction, Serum bilirubin, Serum uric acid