Abstract: Abstract Object The purpose of this research is to observe the effect of taurine on energy metabolism in rats following with traumatic brain injury. Methods 24 rats were randomly divided into sham group, traumatic brain injury group (TBI) and taurine treating group,8 rats in each group. The groups of TBI and taurine were subjected to severe traumatic injury of left brain by lateral fluid pressure device. Then taurine group were injected traurin（200mg/kg）and the other groups were given saline through caudal vein immediately. Intercellular fluid in each group(each group contain 3 time points,1-3h, 22-24h, and 7d) in left brain tissue were collected by using the method of microdialysis, glucose, lactate, glycerol, pyruvate in the samples were measured using CMA600 auto biochemistry analyzer, and calculate the ratio of lactate and pyruvate. Results (1) The level of glucose in left brain tissue had no statistic differences in the three groups after traumatic brain injury; But the level of glucose were increasing significantly in TBT group with time goes.(2)The level of lactate was all higher in TBI group at the three time than those in sham group，and the differences had statistic significance, whereas ,the level of lactate decreased in TBI group with time goes. Taurine could markedly decrease the content of lactate in 24h, which had no significant difference to sham group.(3) After traumatic brain injury, the level of glycerol in damaged hippocampus had no statistic differences to sham group, but it decreased markedly in taurine group.(4)The level of L/P were all higher in TBI group at the 3 time point than those in sham group, and decreased with time goes. The level of L/P in taurine group were all lower than that in TBI group at 3 time point, but it was still markedly higher than that in sham group. Conclution It can appear metabolism function disorder and taurine may make an active effect on adjusting metabolism disorder after traumatic brain injury.

Key words: traumatic brain injury, energy metabolism, glucose, lactate, glycerol, pyruvate