Abstract: Objective: To research the relationship between peripheral neuropathy and Metabolic Syndrome (MS) in 2 type diabetes. Methods: 302 type 2 diabetes patients Were examined by Michigan diabetic neuropathy score and nerve electrophysiological test. Patients were divided into 2 groups according to their blood pressure, glucose levels, blood lipids and waistlines. Results: In the metabolic syndrome group, the prevalence of peripheral neuropathy (57.5%)and Michigan diabetic neuropathy symptom score(4.12±1.89) and sign score(2.15±1.60) were higher than those in non-MS group(44.3%，1.69±1.54，1.56±1.01)(all P<0.05). Peroneal sensory nerve conduction velocity (43.7±4.6m/s in left， 40.0±4.9m/s in right) in MS group were lower than those in non-MS group(46.1±4.0m/s in left， 45.9±4.5m/s in right).The left median sensory nerve conduction velocity(51.7±4.2m/s) in MS group was lower than that of non-MS group(55.5±4.3m/s) (all P<0.05).Multiple regression analysis show that MS was independently related to peripheral neuropathy after adjustment for sex, age, disease duration, blood pressure and blood glucose. OR value was 1.195, P<0.05. Conclusion: Metablic syndrome may be related to the progress of diabetic peripheral neuropathy in type 2 diabetes.

Key words: Metabolic Syndrome, Type 2 Diabetes, Peripheral neuropathy