Abstract: Objective  To investigate whether percutaneous coronary intervention（PCI）causes instability of the respiratory regulation in patients of coronary heart disease with obstructive sleep apnea-hypopnea syndrome(OSAHS). Method   The author conducted a prospective self-control study in which 41 cases were involved by admission order who suffered coronary heart disease with OSAHS, and follow-up treated with PCI. Polysomnograph, echocardiogram and serum test performed not only ahead of PCI but also 3 days and 1 month after PCI respectively. All patients had never been treated with constant positive airway pressure (CPAP) ventilation or any type of operation during the study. Result   There was no significant change in echocardiogram and serum test outcome of the patients throughout our study (P>0.05). The central sleep apnea index(CSAI), the mixed sleep apnea index(MSAI) and the micro-arousal index (MAI) had increased significantly in 3 days after PCI(P<0.01), and then decreased to preoperative levels 1 month later(P<0.01). Conclusion  PCI may provoke transient instability of central respiratory regulation, and increase sympathetic activity, which caused more CSA, MSA and micro-arousal events during sleep periods.

Key words: angioplasty, transluminal, percutaneous coronary, sleep apnea, central, sleep apnea, obstructive, 呼吸中枢