Abstract: [Abstract]  Objective  To investigate the expression and significance of EMMPRIN-MMPs-VEGF system in the
mouse model of breast cancer metastasis. Methods   The expressions of EMMPRIN， MMP-2， MMP-9， VEGF， TIMP-1 and TIMP-2 were measured by immununohistochemistry (IHC) in lung metastasis of breast cancer model.Results  The expressions of EMMPRIN, MMP-2, MMP-9 and VEGF were all present in model mice. And the positive rates of EMMPRIN,MMP-2, MMP-9 and VEGF were significantly higher in metastasis group than those of non- metastasis group (P < 0.05).Conclusion   The components of EMMPRIN-MMPs-VEGF system cooperate with each other, and jointly promote tumor cell growth, invasion and metastasis in the mouse model of breast cancer metastasis.

Key words: breast neoplasms, matrix metalloproteinase 2, matrix metalloproteinase 9, vascular endothelial growth factors, mice, inbred strains, EMMPRIN