Abstract:

[Abstract] Objective  To research the expression of mitofusin-2 (mfn2) and tumor metastasis suppressor genes （nm23）in bladder cancer cells and its correlation with clinical pathological feature． Methods Immunohistochemistry was used to measure the expression of mfn2 and nm23．Sixty-five cases of bladder cancer were sampled，which include fifty cases of male and fifteen cases of female. TNM stage：Forty-seven cases were in stage I; Ten cases were in stage II; Five cases were in stage Ⅲ; Three cases were in stageⅣ. Other fifteen cases were sampled from normal bladder or benign tumor of bladder as control . All cases were collected from department of pathology，affiliated Hospital of hebei union university. Results  The positive expression rate of mfn2 in bladder cancer tissues was significantly higher than those in normal bladder tissues and benign tumor of bladder（χ2 =32.528，P < 0.05）；The positive expression rate of nm23 in bladder cancer tissues was significantly lower than those in normal bladder tissues and benign tumor of bladder (χ2 =19.719，P<0.05)；the high expression level of mfn2 in bladder cancer was associated with tumor differentiation and TNM stage（P＜0.05），but not correlated with age，sex，lymph node metastasis and clinical grade. The low level of nm23 was associated with TNM stage，clinical grade and LN metastasis. Conclusion  The positive expression rate of mfn2 was increased in bladder cancer. It indicated that there was a close relationship between mfn2 and the occurrence and development of bladder cancer；The expression rate of nm23 was decreased in bladder cancer，it may be a predictor for metastasis and prognosis of bladder cancer.

Key words: urinary bladder neoplasms, mfn2, nm23, immunohistochemistry