Abstract: Objective To study the effect of compound coenzymes with vitamin E on liver and kidney Injury Induced by neonatal hyperbilirubinemia. Methods 150 term neonatals with hyperbilirubinemia were chosen as observation groups（According bilirubin divided into mild, moderate and severe groups），45 healthy term or non- hyperbilirubinemia newborns were selected as control group. Serum total bilirubin ,γ-GGT , MDA and Cys-c were measured within 24 hours after charge in．The observation groups were randomly divided into regular and combined treatment groups to study the effect of medicines.Compound coenzymes with vitamin E as well as regular methods were given to combined group while regular group only recived regular methods．All the above biochemical indexes were tested in 7th day.Results MDA in blood were higher in all observation groups (mild, moderate and severe groups)than in control group(P＜0.05)；But the levels of γ-GGT and Cys-c increased compared with control group in moderate and severe groups (P＜0.05)，There were positive corelations(P＜0.05) among the levels of serum total bilirubin and MDA、γ-GGT and Cys-c. Positive linear correlation were found between MDA and γ-GGT、Cys-c（P＜0.01）. After early treatment bilirubin decreased and γ-GGT 、Cys-c and MDA declined,with a faster recovery in combined treatment group than regular group(P＜0．05)．Conclusions In hyperbilirubinemia newborns, Lipid peroxidation activated by bilirubin may cause damages of liver and kidney. Compound coenzymes with vitamin E have protective effect to these damages based in conventional treatment in hyperbilirubinemia.

Key words: hyperbilirubinemia, malondialdehyde, vitamin e, coenzymes, infant, newborn