Abstract: [Abstract] Objective   To investigate the effect of creatine phosphate on postoperative fatigue of patients with gastric carcinoma after operation．Methods   Nighty cases with gastric carcinoma were randomly divided into control group (n=45) and study group (n=45)．Intravenous drip of phosphocreatine was given after anaesthesia induction in study group，and control group received normal saline instead． After operation, the two group patients were all treated with enteral and parenteral nutrition. General performance was observed in both groups. Fatigue score was measured on the day before the operation，the first，third and fifth day after operation．Body weight, triceps skinfold thickness (TSF), mid upper arm circumference (AMC), plasma total protein (TP), plasma albumin (ALB), prealbumin (PA) were detected at the same time． Results   The total effective rate of the control group and the study group were 73.3% and 95.6%, respectively, the difference was statistically significant (P<0.05). Fatigue scores was significantly higher, postoperative TSF, AMC, TP, ALB, PA of two groups were significantly decreased than preoperative, the difference was statistically significant (P<0.05); the above indexes of treatment group were significantly better than the control group, the difference was statistically significance (P<0.05). Conclusion   Creatine phosphate can alleviate postoperative fatigue, improve the nutritious status and promote early rehabilitation of patients．

Key words: stomach neoplasms, postoperative complications, treatment outcome, creatine phosphate sodium, postoperative fatigue syndrome