Abstract: As a new model of pre-cancer, organoid is essential for the basic understanding of tumor characteristic and effective tumor treatment. Organoids derived from prostate play an especially important role in the research of fundamental oncology and anticancer drug screen against prostate cancer. Prostate cancer cell lines and xenografts derived directly from primary human tumors are widely used now as models to study prostate cancer and have proven very valuable. But there are some caveats and shortcomes of these two models that have to be accounted for. Here we outline organoid as a third preclini⁃ cal cancer model which may potentially overcome the shortcomes of cancer cell lines and PDTX. This article aims to summa⁃ rizee recent progress of the role of organoid in prostate cancer research.

Key words: organoid, prostatic neoplasms, X enograft model antitumor assays, review, reclinical model, prostate cancer cell lines