Tianjin Medical Journal ›› 2017, Vol. 45 ›› Issue (1): 108-112.doi: 10.11958/20161148

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Advances in protective effects of thyroid hormone on myocardial mitochondria by sirtuins

XU Qi-yao1, 2, ZHANG Mei1△   

  1. 1 Cardiology Center of the Affiliated Hospital of Logistics University of PAP, Tianjin 300163, China;
    2 Graduate School of Tianjin University of Traditional Chinese Medicine

  • Received:2016-10-14 Revised:2016-11-21 Published:2017-01-15 Online:2017-01-15
  • Contact: ZHANG Mei E-mail:dr_xuqiyao@163.com

Abstract: Abstract:Many studies have confirmed that thyroid hormone (TH) and mitochondria have protective effects on myocardium. The partial subtype of sirtuins (SIRTs) can also be able to protect myocardium by mitochondria, which includes improving ischemia reperfusion injury, improving the pathological cardiac hypertrophy and improvement of heart failure. SIRTs can achieve the protective effect for myocardium mainly through inhibiting mitochondrial permeability transition poreand mitochondrial membrane permeabilization, maintaining balance of regulation of mitochondrial morphology, promoting mitochondrial biogenesis, maintaining the function of autophagy of impaired mitochondria. At the same time, there is an interaction between TH and SIRTs. At present, the role of mitochondria has become more and more concerned in apoptosis and necrosis and its protective effect on cells. This review summarized the protective effect of SIRTs on myocardium through mitochondrial and the influence of the interaction between SIRTs and TH on myocardial protection of mitochondrial.

Key words: thyroidhormones mitochondria, myocardium, heart, deacetylase, review, sirtuins