Abstract: Abstract：MicroRNA (miRNA) is short endogenous non-coding RNAs with the length of 22 nt, it regulates the expression of target genes by binding to the 3′ UTR of mRNA and inducing either miRNA degradation or translational repression. Researchers have found that miRNA regulate a wide range of biological processes, including cell development, differentiation, proliferation and apoptosis. miRNA performs its tumor suppressor or oncogenic function by regulating the expression of target genes and correspondingly regulating the signaling pathways. Diffuse large B cell lymphoma (DLBCL)， the most common B-cell non-Hodgkin lymphoma, is a kind of diseases with an extremely heterogeneity in the clinical manifestation, morphology, immunophenotype, and genetic characteristics. In this review, we summarized the target and signaling pathway of miRNA in the pathogenesis of diffuse large B cell lymphoma in recent years, and its application value in clinical staging, typing, prognosis evaluation and treatment strategies.

Key words: lymphoma, large B-cell, diffuse, microRNAs, review