Abstract: Objective To investigate the clinical effect of the compound anisodine combined with diazepam in the treatment of blepharospasm. Methods The data of 48 patients (52 eyes) with blepharospasm were collected in Tianjin Gongan Hospital from February 2015 to March 2018. The patients were randomly divided into observation group and control group with 24 cases (26 eyes) in each group. The grade of blepharospasm was recorded. The observation group was treated with injecting compound anisodine 2 mL besides the superficial temporal artery combined with injecting diazepam 0.5 mL into orbicularis oculi muscle. Compound anisodine was injected once a day for 14 consecutive days, and diazepam was injected once a week for three consecutive times. The control group was treated with rest and relaxation, and mecobalamin was orally administered 0.5 mg three times a day for 14 consecutive days. The grade of blepharospasm, the total effective rate, the recurrence rate and the safety were assessed in two groups after the therapy. Results The complete remission, significant remission, partial remission rates were 42.31%, 30.77% and 19.23% in the observation group, and they were 15.38%, 23.08% and 26.92% in the control group. There were significant differences in the effects between the two groups (Z=- 2.829, P＜0.01). The total effective rate was 92.31% for the observation group and 65.38% for the control group, showing significant difference in the total effective rate between the two groups (χ2=5.650，P＜0.05). The recurrence rate was 7.69% for the observation group, and it was 38.46% for the control group. There was significant difference in the recurrence rate between the two groups (χ2＝6.933, P＜0.01). The incidence of eyelid ecchymosis was 19.23% in the observation group and which was 11.54% in the control group, with no significant difference between the two groups (χ2＝0.148，P＞0.05). There were no serious side effects or complications in both groups. Conclusion Compound anisodine combined with diazepam is safe, convenient and efficient method in the treatment of blepharospasm．

Key words: Anisodine, blepharospasm, diazepam, injections