Abstract:  Knee osteoarthritis is one of diseases that afflict the middle-aged and old people. Articular cartilage injury is the core of its pathological process. The pathological researches around cartilage damage have become more and more in- deepth, and the existing treatment cannot fundamentally reverse this process. However, with the development of cartilage tissue engineering technology in recent years, especially the use of mesenchymal stem cells has provided a new way to solve this difficulty. At the same time, the application of graphene materials in the medical field has gradually become popular. The use of graphene material properties as a scaffold structure combined with mesenchymal stem cells to seek a new method for cartilage damage repair, this paper will summarize the mechanism of knee cartilage injury, the repair of cartilage by mesenchymal stem cells and the application of graphene scaffold materials, in order to develop new treatment ideas.

Key words: cartilage, articular, mesenchymal stem cell, graphene, knee osteoarthritis, stent material