Abstract:

Objective To explore the effect of bifidobacterium quadruple viable bacteria on intestinal flora based on the use of cefaclor in the treatment of infantile bacterial enteritis. Methods A total of 96 children with bacterial enteritis admitted in our hospital were selected as the research objects, and the patients were divided into the combined group (n=48) and the single drug group (n=48). The single drug group was treated with cefaclor alone, while the combined group was treated with a combination of live combined bifidobacterium, lactobacillus, enterococcus and bacillus cereus tablets and cefaclor. The clinical effects, numbers of microbiota, levels of inflammatory factors [tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-8 (IL-8), interleukin-2 (IL-2)], T lymphocyte subsets and adverse reactions were compared between the two groups. Results The total effective rate of the combined group was higher than that of the single drug group, and the improvement time of symptoms and signs was shorter than that of the single drug group (P<0.05). After treatment, levels of Escherichia coli, TNF-α, CRP and IL-8 decreased in both groups, which were lower in the combined group than those of the single drug group (P<0.05). Bifidobacterium, Lactobacillus, IL-2, and T lymphocyte subsets (CD3⁺, CD4⁺, CD4⁺/CD8⁺) were increased in both groups, and those were higher in the combined group than the single drug group (P<0.05). Adverse reactions occurred in two patients of each groups (P>0.05). Conclusion On the basis of using cefaclor and adding bifidobacterium quadruple viable bacteria in the treatment of bacterial enteritis in children can improve the treatment efficiency, improve the intestinal flora and inflammatory response, and have good safety.

Key words: enteritis, cefaclor, gastrointestinal microbiome, pediatric bacterial enteritis, live combined bifidobacterium, lactobacillus, enterococcus and bacillus cereus tablets