Analysis of the effect of Shufeng Tongqiao decoction combined with methylprednisolone tablets in patients with chronic sinusitis and nasal polyp after operation

doi:10.11958/20242365

Abstract

Abstract:

Objective To analyze the effect of Shufeng Tongqiao decoction combined with methylprednisolone tablets in patients with chronic sinusitis and nasal polyp (CRSwNP) after operation. Methods A total of 104 patients with CRSwNP underwent endoscopic nasal surgery were prospectively selected, and patients were randomly divided into the hormone group (n=52, postoperative methylprednone tablets) and the study group (n=52, postoperative combined treatment with Shufeng Tongqin Decoction). After removal and shedding, 50 cases were included in the hormone group, and 49 cases were included in the study group. The curative effect, lung wind-heat syndrome score, nasal mucosa recovery (assessed by Lund-Kennedy score system) and nasal mucosa remodeling were compared between the two groups. Serum levels of human β-defensin (HBD) -2 and high mobility group protein B1 (HMGB1) were detected by enzyme-linked immunosorbent assay. Results The total control rate was higher in the study group than that of the hormone group （95.92% vs. 80.00%, P<0.05). At 12 weeks after surgery, the lung meridian wind heat syndrome scores, Lund-Kennedy scores and serum HMGB1 level were lower than before surgery in both groups (P<0.05), and the study group was lower than the hormone group (P<0.05). At 12 weeks after surgery, the epithelial injury grading was better in the study group than that in the hormone group (P<0.05), and the basement membrane thickness was thinner than that in the hormone group (P<0.05). Conclusion The joint of Shufeng Tongqiao decoction and methylprednisolone tablets has a better effect on postoperative CRSwNP patients, and it can greatly improve the levels of serum hBD-2 and HMGB1, effectively inhibit nasal mucosal remodeling, and greatly improve the recovery of nasal mucosa.

Key words: sinusitis, nasal polyps, nasal mucosa, methylprednisolone, beta-defensin, HMGB1 protein, Shufeng Tongqiao decoction

CLC Number:

R765.41

Figures/Tables 5

References 21

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组别	n		性别（男/女）	年龄/岁		病程/年
激素组	50		29/21	42.08±6.96		2.83±0.79
研究组	49		27/22	41.57±6.73		3.09±0.85
χ²或t			0.085	0.371		1.577
组别		疾病分期（Ⅰ型/Ⅱ型/Ⅲ型）			体质量指数/（kg/m²）
激素组		14/27/9			23.19±2.73
研究组		16/23/10			23.37±2.85
χ²或t		0.195			0.321

组别	n		性别（男/女）	年龄/岁		病程/年
激素组	50		29/21	42.08±6.96		2.83±0.79
研究组	49		27/22	41.57±6.73		3.09±0.85
χ²或t			0.085	0.371		1.577
组别		疾病分期（Ⅰ型/Ⅱ型/Ⅲ型）			体质量指数/（kg/m²）
激素组		14/27/9			23.19±2.73
研究组		16/23/10			23.37±2.85
χ²或t		0.195			0.321

组别	n	完全控制	部分控制	未控制	总控制
激素组	50	24（48.00）	16（32.00）	10（20.00）	40（80.00）
研究组	49	33（67.35）	14（28.57）	2（4.08）	47（95.92）
Z或χ²		2.307^＊			5.887^＊

组别	n	完全控制	部分控制	未控制	总控制
激素组	50	24（48.00）	16（32.00）	10（20.00）	40（80.00）
研究组	49	33（67.35）	14（28.57）	2（4.08）	47（95.92）
Z或χ²		2.307^＊			5.887^＊

组别	n		肺经风热证积分
组别	n		术前		术后12周		t
激素组	50		18.58±4.16		7.36±2.24		36.904^＊＊
研究组	49		19.76±4.30		5.18±1.62		42.705^＊＊
t			1.388		5.539^＊＊
组别		Lund-Kennedy评分
组别		术前		术后12周		t
激素组		11.64±2.74		5.08±1.16		31.195^＊＊
研究组		12.02±2.80		3.47±0.75		36.085^＊＊
t		0.682		8.183^＊＊