Research progress on the role of high mobility group box-1 in myocardial ischemia 
reperfusion injury

doi:10.11958/20201796

Tianjin Medical Journal ›› 2020, Vol. 48 ›› Issue (11): 1125-1130.doi: 10.11958/20201796

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Research progress on the role of high mobility group box-1 in myocardial ischemia reperfusion injury

CHEN Chuan-bin, HUANG Feng△

Department of Cardiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;

Received:2020-06-28 Revised:2020-08-09 Published:2020-11-15 Online:2020-11-15

CHEN Chuan-bin, HUANG Feng△. Research progress on the role of high mobility group box-1 in myocardial ischemia reperfusion injury[J]. Tianjin Medical Journal, 2020, 48(11): 1125-1130.

Abstract

Abstract: The pathogenesis of myocardial ischemia reperfusion injury is complex. Recent studies have shown that high mobility group box-1 (HMGB1) plays an important role in myocardial ischemia reperfusion injury and is involved in inflammatory response, apoptosis, autophagy and other processes, which has become a potential intervention target for prevention and treatment of myocardial ischemia reperfusion injury. Therefore, this paper reviews the mechanism of HMGB1 in myocardial ischemia reperfusion injury.

Key words: HMGB1 protein, myocardial reperfusion injury, apoptosis, autophagy, inflammatory response

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Research progress on the role of high mobility group box-1 in myocardial ischemia reperfusion injury

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