Predictive value of proximal angle of atherosclerosis carotid plaque and distribution of neovascularization in evaluating the recurrence of cerebral infarction

doi:10.11958/20242130

Abstract

Abstract:

Objective To explore the correlation between the proximal angle of carotid atherosclerotic plaques and neovascularization scores, and their clinical application value in predicting recurrent cerebral infarction. Methods A total of 88 patients who underwent carotid plaque ultrasound examination in our hospital were selected. According to CT/MRI results, patients were divided into the non-cerebral infarction group (45 cases) and the cerebral infarction group (43 cases). Conventional ultrasound examination was performed followed by contrast-enhanced ultrasound. Plaque length, thickness and proximal angle were measured, and the neovascularization score of the proximal end was evaluated using contrast-enhanced ultrasound, and the results were compared and analyzed. Results In the cerebral infarction group, plaque thickness, proximal angle, and neovascularization score were significantly higher than those in the non-cerebral infarction group (P<0.05), while there was no significant difference in plaque length. The proportion of plaques with a proximal neovascularization score of 2 or 3 was higher in the cerebral infarction group than those of the non-cerebral infarction group (79.1% vs. 24.4%, P<0.01). A positive correlation was found between the proximal angle and neovascularization score in all patients (r_s=0.374, P<0.01). There was no significant difference between the area under the ROC curve for neovascularization score in predicting recurrent cerebral infarction and the proximal angle (P>0.05). The optimal cutoff value of the proximal angle was 18.8, and the sensitivity and the specificity for predicting recurrent cerebral infarction were 93.0% and 62.2%. In the cerebral infarction group, seven patients (16.3%) had recurrent infarction within one year, and these patients had higher proximal neovascularization scores, with angles greater than 18.8°. Conclusion There is a strong correlation between proximal angle of carotid plaques and neovascularization score, which has a positive predictive role in the recurrence of cerebral infarction, providing a reliable auxiliary diagnostic basis for clinical practice.

Key words: brain infarction, carotid arteries, atherosclerosis, neovascularization score, proximal angle

CLC Number:

R543.4

Figures/Tables 5

References 20

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组别		n	性别（男/女）		年龄/ 岁		BMI/ （kg/m²）		SBP/ mmHg
非脑梗死组		45	28/17		64.2±7.8		25.8±1.5		127.4±6.1
脑梗死组		43	27/16		65.8±7.1		26.4±1.3		130.0±9.0
χ²或t			0.956		0.997		1.786		1.563
组别	DBP/ mmHg			LDL-C/ （mmol/L）		FPG/（mmol/L）		吸烟指数/ 年·支
非脑梗死组	79.3±6.5			3.2±0.6		5.6±0.8		61.0（0，149.5）
脑梗死组	81.4±7.7			3.3±0.5		5.8±1.4		65.0（0，173.0）
t或Z	1.366			1.128		0.703		0.084

组别		n	性别（男/女）		年龄/ 岁		BMI/ （kg/m²）		SBP/ mmHg
非脑梗死组		45	28/17		64.2±7.8		25.8±1.5		127.4±6.1
脑梗死组		43	27/16		65.8±7.1		26.4±1.3		130.0±9.0
χ²或t			0.956		0.997		1.786		1.563
组别	DBP/ mmHg			LDL-C/ （mmol/L）		FPG/（mmol/L）		吸烟指数/ 年·支
非脑梗死组	79.3±6.5			3.2±0.6		5.6±0.8		61.0（0，149.5）
脑梗死组	81.4±7.7			3.3±0.5		5.8±1.4		65.0（0，173.0）
t或Z	1.366			1.128		0.703		0.084

组别	n	斑块厚度/mm	斑块长度/mm	斑块近心端角度/°	新生血管评分/分
非脑梗死组	45	2.5±0.3	16.4±2.8	17.4±2.3	1.0（0.0，1.0）
脑梗死组	43	3.1±0.2	17.3±2.7	23.6±2.2	2.0（2.0，3.0）
t或Z		11.649^＊＊	1.481	13.087^＊＊	4.825^＊＊

组别	n	斑块厚度/mm	斑块长度/mm	斑块近心端角度/°	新生血管评分/分
非脑梗死组	45	2.5±0.3	16.4±2.8	17.4±2.3	1.0（0.0，1.0）
脑梗死组	43	3.1±0.2	17.3±2.7	23.6±2.2	2.0（2.0，3.0）
t或Z		11.649^＊＊	1.481	13.087^＊＊	4.825^＊＊