Abstract: Abstract: Objective To investigate the distribution and drug resistance of carbapenem-resistant Enterobacteriaceae (CRE) of 2013-2017-year clinically isolated from children in our hospital, and to provide a basis for control and treatment of infections caused by such bacteria. Methods The VITEK 2 Compact automatic microbiological identification drug sensitive instrument was used to carry on the drug sensitivity test to this kind of bacterium, and refer to the CLSI-M100 standard to carry on the drug sensitivity experiment. WHONET5.6 software was used for the result analysis, and χ2 test was used to carry out statistical analysis. Results From 2013 to 2017, 687 strains of CRE were isolated clinically, and the detection rate was 10.64%. The strains were Klebsiella pneumoniae (302 strains), Escherichia coli (213 strains) and Proteus (72 strains). The detection rate of CRE showed an upward trend in 5 years. The specimens were mainly from urine (38.14%) and respiratory tract (30.13%). The resistant rates of CRE strains to aminoglycoside and quinolone antimicrobial agents were < 30%, but which of other beta-caprolactam drugs were more than 70%. Conclusion The strain of CRE shows increasing trend in children’ s infection, and most of them are multi-drug resistant strains.

Key words: Enterobacteriaceae, microbial sensitivity tests, child, TIANJIN, carbapenem-resistant enterobacteriaceae