Abstract: Abstract: Objective To analyze clinical distribution, patients factors and drug resistance of 204 strains of carbapenem resistant pseudomonas aeruginosa (CRPA), and to provide scientific basis for clinical rational and effective use of antimicrobial agents. Methods The VITEK-2 Compact automatic microbial analysis system was used for bacterial species identification and drug sensitivity test of isolated 204 strains of CRPA in our hospital from January 2017 to December 2017. The clinical distribution and specimen sources were analyzed. The influence of different factors on the detection rate of CRPA was compared between groups of patients. The differences of drug resistance of isolated strains were compared between the respiratory tract and non-respiratory tract specimens, and between intensive care unit (ICU) and ordinary ward. Results There were 97 strains of CRPA in ICU and 107 strains of CRPA in ordinary ward in total 204 strains of CRPA. The specimens were mainly from respiratory tract, accounting for 169 strains (82.84%). The rest was from non- respiratory tract, accounting for 35 strains (17.16%). The detection rates of CRPA were significantly higher in patients with underlying disease, use of antibacterial agents for nearly 90 days, invasive procedures, and the detection time of bacterial strains was＞48 hours after admission than those in patients with no underlying disease, no antibacterial drug use for nearly 90 days, no invasive operation, and the detection time of bacterial strains was ≤48 hours after admission (P＜0.01). The drug resistance rates to ceftazidime and ciprofloxacin were significantly lower in the respiratory specimen group than those in the non-respiratory specimen group (P＜0.05), and there were no significant differences in drug resistance rates to 12 remaining antibacterial agents between two groups of patients (P＞0.05). The drug resistance rates were significantly lower in isolated strains of ticacillin/clavic acid, cefoperazone/shubatan, amikacin, cefepime and gentamycin in the ordinary ward than those in ICU (P＜0.05), and there were no significant differences in drug resistance rates of the 9 remaining antibacterial agents (P＞0.05). There were no significant differences in the drug resistance rates between imipenan and meropenem in 204 strains of CRPA (P＞0.05). Conclusion The infection of CRPA occurs frequently in hospital. The drug resistance situation is equally severe in ICU and ordinary ward, and in the respiratory system and non- respiratory system. It should be caused clinical attention.

Key words:  pseudomonas aeruginosa, drug resistance, microbial, carbapenem resistant pseudomonas aeruginosa, clinical distribution, ICU, specimen source, patients factors