Abstract: ETS-related gene (ERG) belongs to the E26 transformation-specific (EST) transcription factor family and plays an important role in the development and production of blood vessels, hematopoietic system and cartilage development. In recent years, more and more studies have found that ERG gene overexpression occurs in some tumors, thereby promoting tumor cell proliferation and tumor angiogenesis, and involving in the occurrence and development of tumors, such as prostate cancer (PCa), Ewing's sarcoma (EWS), leukemia, cartilage tumors. However, the specific mechanism of the action of ERG in these tumors is not yet fully clear. At present, the application of ERG in the diagnosis and prognosis of tumors has become a research hotspot. Some drugs that target ERG and its downstream signaling pathways and target genes are in clinical trials. This article reviews the expression, mechanism of action and clinical application of ERG gene in tumors.

Key words: prostatic neoplasms, sarcoma, Ewing's, leukemia, gene targeting, review, ERG gene