Abstract: Objective　To explore the predictive value of high risk of sepsis score (HRSS) for the mortality risks of septic patients, and compare the difference of the sequential organ failure assessment (SOFA) and quick sequential organ failure assessment（qSOFA). Methods　A total of 125 patients with sepsis admitted to our hospital from February 2016 to June 2018 were retrospectively analyzed. Patients were divided into the survival group (86 cases) and death group (39 cases). The HRSS, SOFA and qSOFA scores were recorded in patients. HRSS score includes patient age, respiratory rate, blood oxygen saturation, pulse, systolic pressure, Glasgow Coma Score (GCS), body temperature and skin abnormalities. SOFA score includes oxygenation index, platelet, bilirubin, creatinine, cardiovascular score and GCS score. qSOFA score includes consciousness, respiratory rate and systolic pressure. HRSS, SOFA and qSOFA scores were calculated. Results　The systolic blood pressure and oxygenation index were lower in the dead group than those of the living group. Data of patient age, skin abnormalities, bilirubin, creatinine, cardiovascular score and proportion of consciousness disorders were significantly higher in the dead group than those of the living group (P＜0.05). The scores of HRSS, SOFA and qSOFA were significantly higher in the dead group than those of the living group (P＜0.05). The areas under the ROC of HRSS, SOFA and qSOFA were 0.795 (95%CI: 0.714-0.876，P＜0.01)，0.828 (95%CI:0.756-0.900，P＜0.01) and 0.624 (95%CI: 0.511-0.736, P＜0.05). When the critical values were 4.5, 9.5 and 2.5, respectively, the Youden index was the largest, which were 0.455, 0.588 and 0.224, respectively. Conclusion　The predicting value of HRSS in the risk of death in sepsis patients is similar to that of SOFA, which is better than that of qSOFA.

Key words: sepsis, death, forecasting, organ dysfunction scores, high risk of sepsis score, quick sequential organ failure assessment