Relationship between SII, RAR and severity of disease and respiratory failure in patients with AECOPD

doi:10.11958/20241172

Abstract

Abstract:

Objective To investigate the relationship between systemic immune-inflammation index (SII), red blood cell distribution width (RDW), albumin (ALB) ratio (RAR) and severity of disease and respiratory failure in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 110 patients with AECOPD were divided into the severe group (n=37) and the non-severe group (n=73). They were also divided into the respiratory failure group (n=26) and the non-respiratory failure group (n=84) according to whether they had respiratory failure. Platelet count (PLT), neutrophil count (NEU), lymphocyte count (LYM), RDW, ALB, SII and RAR were compared between different groups. Multiple Logistic regression method was used to analyze influencing factors of severe and concurrent respiratory failure. Receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of indicators for severe condition and respiratory failure. Results Compared with the non-severe group, there were increased NEU, SII, RDW and RAR, and decreased PLT and LYM in the severe group (P<0.05). Compared with the non-respiratory failure group, there were increased NEU, SII, RDW and RAR, and decreased LYM and ALB in the respiratory failure group (P<0.05). Multivariate Logistic regression analysis showed that increased SII and RAR were independent risk factors for severe condition or respiratory failure in patients with AECOPD. ROC curves indicated that the area under the curve (AUC) of SII combined with RAR for predicting severe condition and respiratory failure in patients with AECOPD were 0.882 (0.806-0.935) and 0.908 (0.837-0.954), both of which were higher than those of SII or RAR alone (P<0.05). Conclusion Combination of SII and RAR can effectively help to evaluate the condition and the occurrence of respiratory failure in patients with AECOPD.

Key words: pulmonary disease, chronic obstructive, acute lung injury, respiratory insufficiency, systemic immune-inflammation index, red blood cell distribution width to albumin ratio

CLC Number:

R563

Figures/Tables 10

References 18

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组别	n	男性	年龄≥60岁	吸烟	饮酒	基础疾病
组别	n	男性	年龄≥60岁	吸烟	饮酒	糖尿病	高血压
非重症组	73	59（80.8）	65（89.0）	41（56.2）	18（24.7）	6（8.2）	31（42.5）
重症组	37	28（75.7）	35（94.6）	18（48.6）	8（21.6）	6（16.2）	16（43.2）
χ²		0.393	0.916	0.558	0.125	1.616	0.006

组别	n	男性	年龄≥60岁	吸烟	饮酒	基础疾病
组别	n	男性	年龄≥60岁	吸烟	饮酒	糖尿病	高血压
非重症组	73	59（80.8）	65（89.0）	41（56.2）	18（24.7）	6（8.2）	31（42.5）
重症组	37	28（75.7）	35（94.6）	18（48.6）	8（21.6）	6（16.2）	16（43.2）
χ²		0.393	0.916	0.558	0.125	1.616	0.006

组别	n	男性	年龄≥60岁	吸烟	饮酒	基础疾病
组别	n	男性	年龄≥60岁	吸烟	饮酒	糖尿病	高血压
无呼吸衰竭组	84	66（78.6）	75（89.3）	46（54.8）	23（27.4）	7（8.3）	38（45.2）
呼吸衰竭组	26	21（80.8）	25（96.2）	13（50.0）	3（11.5）	5（19.2）	9（34.6）
χ²		0.058	1.133	0.181	2.761	2.426	0.916

组别	n	男性	年龄≥60岁	吸烟	饮酒	基础疾病
组别	n	男性	年龄≥60岁	吸烟	饮酒	糖尿病	高血压
无呼吸衰竭组	84	66（78.6）	75（89.3）	46（54.8）	23（27.4）	7（8.3）	38（45.2）
呼吸衰竭组	26	21（80.8）	25（96.2）	13（50.0）	3（11.5）	5（19.2）	9（34.6）
χ²		0.058	1.133	0.181	2.761	2.426	0.916

组别	n		NEU/（×10⁹/L）	PLT/（×10⁹/L）			LYM/（×10⁹/L）
非重症组	73		4.11（3.23，5.02）	180.0（140.0，237.0）			1.30（1.06，1.64）
重症组	37		7.48（5.05，10.76）	132.0（83.0，230.0）			0.86（0.70，1.02）
Z			6.317^＊＊	2.300^＊			4.998^＊＊
组别		SII			RDW/%	ALB/（g/L）		RAR
非重症组		568.8（315.0，851.3）			13.63±0.87	36.62±4.69		0.38±0.07
重症组		1 077.0（757.7，1 895.6）			15.00±1.69	37.26±4.75		0.41±0.09
Z或t		4.894^＊＊			4.646^＊＊	0.670		2.007^＊