Abstract:

 [Abstract]   Objective   To explore the clinical value of the different components of glycosylated hemoglobin in pa-
tients with coronary artery disease (CAD).   Methods   A total of217patients were divided into3groups: CAD group (groupⅠ,n=60), CAD patients without acute coronary syndrome (ACS) and with diabetes mellitus group (groupⅡ, n=60) and ACSpatients with diabetes mellitus group (group Ⅲ,n=97). Fifty-eight healthy volunteers in the same time period were selected as control group. The values of fructose glycosylated hemoglobin (HbA1a), lactose glycosylated hemoglobin (HbA1b), glucose glycosylated hemoglobin (HbA1c), hemoglobin P3component (HbP3), hemoglobin A0component (HbA0), unstable glycosylated hemoglobin (LA1c/CHb1) and alkali-resistant hemoglobin (HbF) were measured. These parameters were compared between4groups. Logistic regression was used to analyze factors that influencing CAD and CAD with diabetes mellitus. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficiency of these factors.  Results  There were significant differences in titers of HbA1b, HbA1c, HbP3and HbA0between groupⅠ, groupⅡ, group Ⅲ and control group (P<0.01, or P<0.05). There were no significant differences in levels of glycosylated hemoglobin parameters between group Ⅱ and group Ⅲ (P>0.05). Logistic regression and ROC curve analysis showed that HbA1c and HbP3were independent effects of CAD, and there were some diagnostic efficiency of CAD. The diagnostic efficiency of ROC curve was consistent in HbA1c and HbP3between group Ⅱ and group Ⅲ.  Conclusion   Levels of HbA1b, HbA1c, HbP3and HbA0are closely related to CAD and CAD with diabetes mellitus. HbA1c and HbP3are independent effects of CAD and, there are some diagnostic efficiency in CAD.

Key words: hemoglobin A, glycosylated, Coronary disease, HbA1b, HbA1c, HbP3, HbA0