Abstract:

[Abstract]   Objective   To study the effect of red cell and plasma protein parameters on progression, prognosis and
recurrence of cerebral infarction.   Methods   Clinical data from 105 patients with cerebral infarction were analyzed. The patients were divided into four paired groups: progressive stroke group and complete stroke group, short-term favorable prognosis group and short-term unfavorable prognosis group, long-term favorable prognosis group and long-term unfavorable prognosis group, relapsed cerebral infarction group and not relapsed group by different criterion. The red cell and plasma protein parameters were compared between groups.   Results   There were significantly higher mean corpuscular volume（fL： 85.92±4.50 vs 83.79±4.64， t=2.164， P < 0.05）, red cell distribution width（fL： 13.50±2.45 vs 11.90±2.90， t=2.694， P < 0.01）, globulin（g/L ： 27.46±4.33 vs 24.79±4.03， t=3.029， P < 0.01） and lower albumin（g/L ： 39.00±3.86 vs 42.89±4.45， t=4.242， P <0.01） in progressive stroke group than those of complete stroke group. The elevated red cell distribution width, reduced albumin were the risk factors of progressive stroke. In the short-term unfavorable prognosis group, red cell distribution width was significantly higher than that in short-term favorable prognosis group（fL： 13.90±2.45 vs 12.00±2.12，t=2.905， P < 0.01）. The red cell distribution width was positively correlated with mRS scores assessed 3 months and 18 months after cerebral infarction(P < 0.01).   Conclusion   Progressive stroke rate increases in cerebral infarction patients with elevated red cell distribution and reduced albumin; Red cell distribution width has a certain reference value for forecasting the prognosis of cerebral infarction .

Key words: brain infarction, blood proteins, Serum albumin, the red blood cell distribution width, mRS score