Abstract:

[Abstract]   Objective   To study the relationship between coronary artery disease (CHD ) and interleukin-6 (IL-6),
TNF-α and IL-10.   Methods   Patients with CHD were included in CHD group (n=628) and patients without CHD con?firmed by coronary angiography were selected in control group (n=540) . The recorded data included age, body mass index (BMI) and serum levels of glucose (GLU), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDLC) and low density lipoprotein-cholesterol (LDL-C). Meanwhile serum levels of IL-6, TNF-α, IL-10 were determined by ELISA.   Results   Serum levels of BMI, LDL-C, TG were higher in CHD group than those in control group（P < 0.01）. The serum level of HDL-C was significantly lower in CHD group than that in control group（P < 0.01）. Serum levels of IL-6（P <0.05）and TNF-α（P <0.01） were higher in CHD group than those in control group. The serum level of IL-10 was significantly lower in CHD group than that in control group（P <0.01）.   Conclusion   IL-6 and TNF-α are involved in the development of CHD. IL-10 can inhibit inflammation and protect vessel integrity

Key words: coronary disease, interleukin-6, interleukin-10, tumor necrosis factor-alpha