Abstract: Objective To investigate the prediction value of serum pentraxin 3 (PTX3) combined with CHA2DS2- VASc score for cerebral infarction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and atrial fibrillation. Methods A total of 198 OSAHS patients with atrial fibrillation were selected. According to whether cerebral infarction occurred during the follow-up period, patients were divided into the cerebral infarction group (36 cases) and the non-cerebral infarction group (162 cases). The indexes were compared between the cerebral infarction group and the noncerebral infarction group. The correlation between serum PTX3 and other indexes in OSAHS patients with atrial fibrillation were analyzed. The risk factors of cerebral infarction in OSAHS patients with atrial fibrillation were analyzed. The predictive value of PTX3 combined with CHA2DS2-VASc score for cerebral infarction in patients with OSAHS complicated with atrial fibrillation was analyzed. Results The systolic blood pressure, low density lipoprotein cholesterol (LDL-C), left atrial diameter (LAD), apnea hypopnea index (AHI), CHA2DS2- VASc score and PTX3 were significantly higher in the cerebral infarction group than those in the non-cerebral infarction (P＜0.05). Serum PTX3 levels were positively correlated with LDL-C, LAD, AHI and CHA2DS2-VASc scores in patients with OSAHS and atrial fibrillation (P＜0.05). Multivariate Logistic regression analysis showed that the increased LAD, AHI, CHA2DS2-VASc score and PTX3 were risk factors for cerebral infarction in patients with OSAHS and atrial fibrillation (P＜0.05). The areas under the curve of PTX3 and CHA2DS2-VASc scores in predicting cerebral infarction in patients with OSAHS complicated with atrial fibrillation were 0.785 (0.695-0.875) and 0.794 (0.698-0.890), respectively. The combined analysis of PTX3 and CHA2DS2-VASc scores showed that the sensitivity and Youden index were significantly improved. Conclusion Serum PTX3 combined with CHA2DS2-VASc score has a higher predictive value for cerebral infarction in patients with OSAHS and atrial fibrillation.

Key words: sleep apnea, obstructive, atrial fibrillation, brain infarction, pentraxin-3, CHA2DS2-VASc score