Abstract: 【Abstract】 Objective: To evaluate and assess the efficacy of umbilic cord blood stem cell transplantation through hepatic artery in the therapy of patients with non-posthepatitic cirrhosis. Methods: 10-15ml umbilic cord blood stem cells were transplanted into the liver through hepatic artery in 12 patients with non-posthepatitic cirrhosis. Alanine aminotransferase(ALT), albumin(ALB), total bilirubin(TB) and fibrinogen(FIB) were observed at pre-transplantation,1 week ,1 month and 3 months after transplantation were measured and analyzed. Results: All patients were transplanted successfully. The symptoms such as anorexia, fatigue,and distension/ascites begun improved at 1 week post-transplantation and showed significant improvement at 3 months post-transplantation （P＜0.05）.ALT increased at 1 week post-transplantation compared with pre-transplantation （P＜0.01）,while ALB decreased slightly at 1 week after transplantation（P＜0.05）, TB showed insignificant increase after transplantation（P＞0.05）, while FIB decreased insignificantly at the same time（P＞0.05）.All variable resumed to pre-transplantation level at 1month post-transplantation（P＞0.05）.There was significant improvement 3 months after transplantation（P＜0.05）,but the level of ALB and FIB were still under the lower limit. No severe effect and serious complication occurred. No occupying lesions was detected in liver by CT or B-ulreasound at 3 month post-transplantation. Conclusion: The transplantation of umbilic cord blood stem cell through hepatic artery in therapy of patients with non-posthepatitic cirrhosis was a safe and recommendable method with creditable short-term efficacy，but still need further research.

Key words: stem cell, umbilic cord blood, non-posthepatitic cirrhosis, hepatic artery, transplantation, interventional radiology.