Abstract: Objective：Study on the function and condition of the vascular endothelial system and coagulation system in the patients with the chronic heart failure(CHF), assay the mechanisms of the dysfunction. Methods：Using the IL ACL-9000 blood coagulation instrument assay the von Willebrand Factor antigen(vWF:Ag). The TF:A was measured by chromogenic substrate method. The TAT was measured by ELISA. Results：Compared the control with the patients group, vWF:Ag, TF:A and TAT were increased significantly in the patients group（P<0.01）. vWF:Ag and TF:A in the HF patients with NYHA Class Ⅱ were remarkably higher than the NYHA Class Ⅰ（P<0.01）. vWF:Ag, TF:A and TAT in the HF patients with NYHA Class Ⅲ were remarkably higher than the NYHA Class Ⅱ（P<0.01）. There was no relationship between the vWF:Ag and the TF:A, the TAT（r=0.2128, r=0.4003, P>0.05）, and the strong positive relationship between the TF:A and the TAT（r=0.6946，P<0.01）. Conclusion：There was severe vascular endothelial cells damage in the patients with HF, and the endothelial injury caused the coagulation system to activate, and brought the worse thrombosis risk. The level of the vWF:Ag, TAT and TF:Ag were closely connected with heart failure progress in CHF patients.

Key words: chronic heart failure, dysfunction, coagulation, endothelial cells damage