Abstract: Abstract:Objective observe influence of atrial fibrillation on serum BNP levels of patients whit chronic heart failure. Method 120consecutive patients with signs and symptoms of heart failure who were referred to the heart failure at the between Jan 2009 and Mar 2010 were included on the study. atrial fibrillation group（52） and（68） were divided according to ECG，All subject were divided three groups according to New York Heart Association(NYHA). The plasma concentration of BNP was determined with ELISA assay.Results Plasma concentration of BNP in AF was significantly higher than that in si?nus rhythm group with the same heart fuction.Conclusion Atrial fibrillation is an independent determinant of increased BNP levels. This asso?ciation should be taken into account when BNP levels are used in the diagnosis of heart failure in pa?tients with atrial fibrillation.

Key words: Atrial fibrillation, Chronic congestie heart failure, BNP