Abstract: Atrial fibrillation (AF) is the most common tachyarrhythmia. At present, the main treatment methods of AF are anticoagulation, controlling ventricular rate and maintaining sinus rhythm. However, the mechanism of AF has not been elucidated, and the above treatment methods still have certain limitations. Phosphatidylin-3-kinase/protein kinase B (PI3K/AKT) signal transduction path is an important pathway involved in the occurrence and development of AF, which can be involved in the pathophysiological process related to AF through mediating atrial fibrosis, inflammation response, oxidative stress and neuroendocrine function regulation. In-depth study of the role of PI3K/AKT signal transduction pathway in AF can provide valuable guidance for the prevention, treatment and prognosis assessment of AF.

Key words: atrial fibrillation, fibrosis, oxidative stress, inflammation, PI3K/AKT signaling pathway, neuroendocrine