Abstract: Abstrac Objective: To study If there is a synergistic effect on leading to left ventricular remodelingwhen the patient both suffer from homocystinemia and hypertension.Methord:Choose 275 TianjinChest Hospital Cardiology in-patients and divide them into 4 groups based on their plasma homocysteine level and whether suffer from hypertension。Then analyse and compare left ventricular relative thickness、Left ventricular mass index（LVMI）、the proportion of left ventricular remodeling in the 4 groups. Results:The H- hypertension Group has a higher level in left ventricular relative thickness、Left ventricular mass index（LVMI）、the proportion of left ventricular remodeling copared to the other 3 groups[（0.45±0.11）Vs（0.43±0.09）Vs（0.42±0.15）Vs（0.33±0.12），（130.12±55.73）Vs（110.17±58.20）Vs（110.35±44.86）Vs（93±20.33），（40.2%）Vs（22.7%）Vs（24.3%）Vs（3.1%），p＜0.05]. Conclusion: Homocysteine and systolic pressure are both independent risk factors for left ventricular remodeling and they have a synergistic effect on leading to left ventricular remodeling.Which stress out that we should control blood pressure as well as reduce plasma homocysteine level

Key words: hyperhomocysteinemia, hypertension, risk factors, retrospective studies, Logistic models, left ventricularremodeling