Abstract: Colitis associated cancer (CAC) is a worldwide medical problem. Tumor microenvironment is the hot spot of current research. Intestinal flora imbalance is closely related to the incidence of CAC and aggravates colitis-induced CAC. With the development of microecology, intestinal flora has received much attention in CAC research. This article outlines the relationship between intestinal flora and diet, inflammatory mechanisms and intestinal mucosa during CAC development, and the related research in diagnosis and treatment. It is mainly discussed that the intestinal flora may become a new target of CAC mechanism and its related application prospects.

Key words: inflammation, intestinal neoplasms, food habits, diagnosis, therapy, review, colitis associated cancer