Abstract: Objective To investigate the analgesia effect and safety of conducting ultrasound-guided fascia iliaca compartment block (FICB) by dexmedetomidine (Dex) combined with ropivacaine in femoral surgery during perioperative period. Methods During the period from June 2016 to March 2019, 102 patients who underwent femoral surgery in the hospital were included, and patients were divided into Dex group (n=55, ultrasound-guided FICB by Dex combined with ropivacaine before general anesthesia) and control group (n=47, ultrasound-guided FICB by ropivacaine before general anesthesia) according to different analgesia methods during perioperative period. The intraoperative dosage of remifentanil,postoperative awake time and extubation time were recorded. The pain visual analogue scale (VAS) and Ramsay sedation score were performed to assess analgesia and sedation effects, respectively. The adverse reactions were also recorded.Results The intraoperative dosage of remifentanil was significantly less in Dex group than that in control group [(0.68± 0.17) vs. (0.79±0.19) mg, P＜0.01]. Before induction of anesthesia,VAS scores of limb braking and isometric contraction of quadricepsat 6 h, 12 h, and 24 h after surgery were significantly lower in Dex group than those in control group (all P＜0.05).At 12 h, 24 h and 72 h after surgery, the sufentanil consumption in analgesic pump was significantly lower in Dex group[(11.10±1.93), (25.15±5.62), (60.56±8.65) μg] than that of control group [(14.34±2.67), (31.64±7.12), (92.49±13.83) μg, P＜0.05]. There was no significant difference in Ramsay sedation score between the two groups at any time point during perioperative period. There were multiple adverse reactions in both groups. However, the incidence of them was relatively low. The incidence of dry mouth was significantly higher in Dex group than that in control group (16.36% vs. 4.26%, P＜0.05). There was no significant difference in the incidence of other adverse reactions between the two groups. Conclusion Conducting ultrasound-guided FICB by dexmedetomidine combined with ropivacaine in femoral surgery during perioperative period can play good analgesia effect, which can reduce intraoperative and postoperative usage of analgesics, without affecting sedation effect. And the safety is good, but need to pay attention to postoperative dry mouth symptoms.

Key words: analgesia, femur, perioperative period, femoral surgery, dexmedetomidine, ropivacaine, fascia iliaca compartment block